BENEV Company Inc. is a pharmaceutical, cosmeceutical, and biotechnology company, founded in Orange County, California that serves the medical skin care market with scientifically advanced, results-driven skin care solutions. BENEV Cosmeceuticals: BENEV develops and produces BENEV brand cosmeceutical products in its own FDA-licensed manufacturing facility. Our products are distributed exclusively through physicians in the U.S. and through a network of distributors internationally. The BENEV line includes both physician-only retail skin care products and clinical use only products to support skin care specialists. We share our knowledge and expertise through education and training programs that focus on giving our customers the tools they need to build their businesses through esthetic services and retail.

Spectrum Designs Medical is a designer, manufacturer and distributor of solid silicone facial, specialty and custom implants for the plastic and reconstructive surgery marketplace. We are committed to consistently ensure a high level of customer service and satisfaction in all products that we produce.Spectrum Designs Medical is dedicated to the challenge of maintaining the highest production quality standards while serving the advancing demands of the medical professional. From our FDA registered facility and ISO 13485 certified Quality System we consistently supply surgeons with a wide variety of implants to provide the physician the power to reshape and restore the patients symmetry, aesthetics and quality of life.

Medical device manufacturing company that specializes in home-use beauty devices that deliver treatment options previously only available at a medical professional’s office.

The NovaPulse CO2 laser provides a quick and easy-to-use method for physicians seeking to expand their practice capabilities. It combines the advantages of laser precision with a familiar, scalpel-like feel. The flexible fiber delivery system, utilizing patented hollow waveguide technology, allows the surgeon to effortlessly access difficult-to-reach treatment sites and cut, ablate, or vaporize tissue, as directed. Surgeons experience quick procedure time, precise control, and an expanded array of office-based procedures, while patients experience shorter recovery time and minimal post-operative discomfort, allowing them to resume their normal activities earlier than with conventional surgery.

With the new UltraPulse® SurgiTouch™ CO2 laser system, you can now focus on the surgery — not the set-up. The UltraPulse SurgiTouch takes CO2 laser surgery to the highest levels of ease-ofuse, control and precision. Simply select the surgical specialty, application and the system will suggest a delivery device with pre-set starting parameters. The UltraPulse SurgiTouch scans a highly focused laser beam rapidly over a predetermined spot size (potentially up to 15mm), eliminating conduction of heat to adjacent tissue. It incorporates the most advanced technologies in CO2 laser surgery today: the 60 Watt char-free pulse energy with the SurgiTouch user interface and scanner system. • Automatic pre-set starting parameters, by specialty and by application • Suggests a delivery device, tailored to meet multiple surgical needs • Scans a highly focused laser beam over a predetermined spot size (potentially up to 15mm) • Char-free tissue effects in the SurgiTouch and UltraPulse mode • Highest pulse energy and average power in the medical laser industry • Physician-selectable pulse energy settings (2 to 225mJ) • Delivery devices and accessories for every specialty • Easy-to-maneuver, compact design and convenient storage • Easy-to-use touch screen controls with large control display • Clinical education staff for training and support

Lumenis’ cost-effective line of compact CO2 laser systems offer 30W or 40W powers combining portability and uncompromised performance. All systems feature an extremely accurate laser beam (as fine as 0.1mm) as well as Pulsed and Superpulse operation modes. The units are easily transported and especially advantageous for small operating theatres or offices. • Multidisciplinary • Wide range of accessories • Compact and portable • For use in hospitals, private clinics or outpatient facilities • SurgiTouch compatible for char-free, layer-by-layer tissue ablation • Designed for simplicity of operation and maximum safety • Soft touch control panel and user prompts • Alphanumeric messages walk user through each step of operation • Programmable memory protocols • Adjustable bright 3mW He-Ne aiming beam

Lumenis’ cost-effective line of compact CO2 laser systems offer 30W or 40W powers combining portability and uncompromised performance. All systems feature an extremely accurate laser beam (as fine as 0.1mm) as well as Pulsed and Superpulse operation modes. The units are easily transported and especially advantageous for small operating theatres or offices. • Multidisciplinary • Wide range of accessories • Compact and portable • For use in hospitals, private clinics or outpatient facilities • SurgiTouch compatible for char-free, layer-by-layer tissue ablation • Designed for simplicity of operation and maximum safety • Soft touch control panel and user prompts • Alphanumeric messages walk user through each step of operation • Programmable memory protocols • Adjustable bright 3mW He-Ne aiming beam

ZYDERM® and ZYPLAST® injectable collagen implants are still widely used as safe and effective choices for smoothing lines, wrinkles and scars, and for defining the lip border. ZYDERM® and ZYPLAST® supplement the skin's natural collagen to treat fine lines, wrinkles, shallow scars and thin-skinned areas. ZYDERM® and ZYPLAST® implants are indicated for the correction of contour deformities of the dermis in non-weight bearing areas. These implants have been employed successfully in many areas of the body to correct distensible acne scars, glabellar frown lines, nasolabial folds, and other soft tissue defects.

Myobloc® (Botulinum Toxin Type B) Injectable Solution is indicated for the treatment of patients with cervical dystonia to reduce the severity of abnormal head position and neck pain associated with cervical dystonia.

Dysport® is a versatile prescription medicine that has a wide range of therapeutic uses. Dysport® was first adapted to treat medical conditions but has gained popularity because it is a simple and effective way of reducing facial wrinkles without the need for surgery. In addition, it keeps the muscles immobile for several months so people often lose the habit of frowning or squinting. This helps prevent the lines from returning.

BOTOX® (Botulinum Toxin Type A) Purified Neurotoxin Complex is a sterile, vacuum-dried purified botulinum toxin type A, produced from fermentation of Hall strain Clostridium botulinum type A grown in a medium containing casein hydrolysate, glucose and yeast extract. It is purified from the culture solution by dialysis and a series of acid precipitations to a complex consisting of the neurotoxin, and several accessory proteins. The complex is dissolved in sterile sodium chloride solution containing Albumin Human and is sterile filtered (0.2 microns) prior to filling and vacuum-drying.

Plush lined 3-panel elastic for comfortable feel against the skin. Provides consistent compression throughout recovery and is fully adjustable with contact closure.

Abdominal Binder w/velcro

Rainey Compression Essentials, founded in1990 by apparel designer Russell Rainey, is an industry leader of pre- and post-operative garments. Surgeons were seeking a higher level of quality, service and innovation to aid in the critical healing process of their patients. After collaborating with surgeons, nurses and staff, a new generation of compression garments took shape that met all medical compression requirements without sacrificing the comfort of patients. At Rainey, we're continually working to improve the construction and features of our garments to incorporate new technical advances that include comfortable, breathable DuPont Power Lycra fabric, an easier to use crotch opening and reinforced seams. We also feature a distinctive line of consultation garments that include gowns, camisoles and robes for easy physical exams and elegant patient modesty.

Adson Tissue Forceps

The Aramis uses a combination of: 1. A patented wavelength, 2. Pulse modulation, 3. Contact cooling, to produce a sub-coagulative thermal injury leading to a temporary alteration in the size and function of the overactive sebaceous gland. This thermal effect kills bacteria and reduces sebum production. 1. The ideal wavelength: 1.54 �m At 1.54 �m the patented wavenlength of the Aramis is ideally absorbed by water, directly targeting the sebaceous glands. 2. A laser shot in pulses: Thanks to the principle of pulse train mode, the laser effects will take place at the level of the sebaceous glands located deeper in the dermis. The number of pulses will depend on the required depth of penetration (down to 900 microns). 3. A constant autoregulated contact cooling system: Auto-regulated at 5�C, the handpiece provides: Desensitization of the treatment area. Painless gentle cooling with no erythema or edema. 1 + 2 + 3 = Ideal penetration depth, targeting the sebaceous gland. Thermally reduces sebum production. Induces collagen production to simultaneously reduce the incidence of acne scarring. Fast, no pre-treatment regimen. Treatment virtually painless. No associated side-effects

Patients love the Regenlite™ Pulsed Dye Laser because there is no pain, just a sensation as if warm water drops were being applied to the skin. Backed by numerous clinical research articles and the clinical experience of over 500 aesthetic practices worldwide, The Regenlite™ Pulsed Dye Laser offers swift and effective treatments with no need for cooling or anesthesia and little or no visible after-effects, allowing the patient to resume their normal routine quickly. The Regenlite™ Pulsed Dye Laser has three treatment modes: skin rejuvenation laser mode, vascular laser mode and acne mode. For skin rejuvenation and acne, the laser delivers low fluency visible yellow light at 585nm with exclusive Smartpulse technology. This stimulates the body’s natural responses to produce new collagen and treats skin diseases such as Acne Vulgaris and Psoriasis. By switching the laser to the vascular mode, the operator is provided with all the treatment options of a standard pulsed dye vascular laser. The Regenlite™ Pulsed Dye Laser, is making a real difference in patient’s lives and in the success of your aesthetic practice.

The 1540-nm Er:Glass Laser System for Acne, Skin Rejuvenation and Smoothing of Scars The laser beams of the ARAMIS system penetrate deep into the skin and are absorbed by the water in the tissue. You can use ARAMIS to treat a variety of indications: Active acne through the destruction of the sabaceous glands by warming up of the tissue. This reduces the sebum production. Skin rejuvenation by stimulating the collagen neo- synthesis. This leads to an improvement of the skin structure as well as a reduction of wrinkles and pore size. Scars and acne scars by specifically stimulating collagen neosynthesis.

Ideal for use after abdominoplasty and upper and lower abdominal liposuction. Features a 10" wide foam backing that offers comfort, support, and compression without slippage. The two panel design provides greater adjustment to the contour of the patient’s upper and lower abdomen.

Abdominal Compression

For immediate post-operative wear Ultra soft stretch fabric Front adjustable Velcro closure Recommended for abdominal and flank procedures

Ideal for use after abdominoplasty and upper and lower abdominal liposuction. Features a 9" wide foam backing that offers comfort, support, and compression. The single panel binder features a non-rolling elastic band.

Abdominal Compression

Plush lined 3-panel elastic for comfortable feel against the skin. Provides consistent compression throughout recovery and is fully adjustable with contact closure.

Syneron(TM) Medical Ltd. has launched the sleek eMatrix(TM) treatment system, a portable touch-screen device that allows physicians to program dermatological procedures requiring skin resurfacing. An exciting advancement in aesthetic procedure technology that helps physicians to treat more patients in more locations, eMatrix utilizes Matrix RF(TM), the world’s first RF-only technology for fractional ablation and skin resurfacing, which was FDA-cleared and received the CE Mark for wrinkle reduction in August. The new eMatrix system uses fractional tissue heating to provide ablation and effective resurfacing.

Biocompatibles has announced the filing for CE Mark approval by the Company’s development and marketing partner Merz Pharmaceuticals GmbH for the Cosmetic Dermal Filler Bead. The product has been licensed to Merz and will be manufactured by Biocompatibles’ German subsidiary, CellMed AG. The global market for aesthetic dermal filler products1 is at least $760m2. The current market consists mainly of products manufactured from collagen and hyaluronic acid. Biocompatibles’ subsidiary CellMed manufactures the Cosmetic Dermal Filler Bead from highly purified alginate material, using a proprietary manufacturing process.

Stiefel Laboratories has announced the expansion of its REVALESKIN skin care line with three new products on the heels of the extraordinarily successful introduction of the core REVALESKIN(R) skin care system (Facial Cleanser, Day Cream with SPF 15 sunscreen and Night Cream). According to a Global Industry Analysis Report (March 2008), the market for anti-aging products is predicted to reach $115.5 billion by 2010. With the launch of these three new products, the REVALESKIN(R) skin care line will meet consumer demand for professional take-home beauty products designed for targeted treatment of problem skin areas.

Johnson & Johnson Pharmaceutical Research & Development has announced that it received a Complete Response letter from the U.S. Food and Drug Administration (FDA) regarding its New Drug Application (NDA) for ceftobiprole for the treatment of complicated skin and skin structure infections, including diabetic foot infections. The FDA has indicated that they cannot approve the NDA for ceftobiprole at this time. They have asked J&JPRD to conduct additional audit work of clinical investigator sites and to address specific questions related to site monitoring.

LEO Pharma has launched a new treatment gel Xamiol® for scalp psoriasis. This gel formulation contains the proven combination of the Vitamin D analogue calcipotriol 50 microgram/g (as monohydrate) and the corticosteroid betamethasone 0.5 mg/g (as dipropionate). It is indicated for once-daily topical treatment of scalp psoriasis in adults and is recommended for four weeks and thereafter repeat treatment can be initiated under medical supervision. Xamiol®, an almost clear and odourless gel, differs from traditional scalp psoriasis treatments.

Dermipsor Ltd. has reported detailed analysis of the results for the Phase 2b clinical trial of its product DPS-101. To be used in the treatment of psoriasis patients, DPS-101 is a new topical non-steroidal combination drug. It is a mix of two active ingredients - calcipotriol and nicotinamide. The multi-centre trial included 168 bilateral patients. Each side of the body of these patients was treated separately to evaluate the effectiveness of various doses of the medication. At the end of this 12 week study, half of the patients who received the highest dose of the drug achieved a condition of “clear to almost clear”. This is a significant improvement as compared to placebo.

Obagi Medical Products, Inc has announced the publication of a study of its copper-zinc malonate eye treatment ELASTIderm™ in the September 2008 issue of the dermatology journal, Experimental Dermatology. Findings of the study conducted at Jefferson Medical College suggest that six weeks of ELASTIderm treatment can boost the biosynthesis of elastin in skin helping to repair and regenerate the elastic fiber network. It reduces the number of visible wrinkles by restoring the skin’s elasticity. The product uses a bi-mineral complex technology.

Medivir has submitted an application to the European medical regulatory authorities for marketing authorization for its product Lipsovir®. The cream, a patented combination of acyclovir (an antiviral agent) and hydrocortisone (an anti-inflammatory agent) is used for preventing as well as treating cold sores. None of the already existing products on the market that are indicated for the condition have the effect that Lipsovir promises.

The U.S. Food and Drug Administration has approved updated labeling changes for Genentech Inc.’s Raptiva (efalizumab) to warn of  the dangerous infection risks (like PML) associated to its usage. A once-weekly injection, Raptiva is approved for treatment of plaque psoriasis in adult candidates for phototherapy or systemic (whole body) therapy. Also, a risk of immune system’s permanent suppression with repeated administration of Raptiva has been indicated for kids below 14 years.

The U.S. Food and Drug Administration has given 510(k) clearance to Reliant Technologies Inc. for three novel Fraxel re:pair laser hand pieces. This enhanced potential of the Fraxel re:pair laser system will provide physicians with an option for surgical treatment and skin resurfacing. As part of the Fraxel re:pair Complete Fractional Ablative Workstation, all of the three surgical hand pieces can be used alone or along with each other, with no need to turn the system off for changing the hand pieces.